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        <title>Frontiers in Artificial Intelligence | New and Recent Articles</title>
        <link>https://www.frontiersin.org/journals/artificial-intelligence</link>
        <description>RSS Feed for Frontiers in Artificial Intelligence | New and Recent Articles</description>
        <language>en-us</language>
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        <pubDate>2026-05-24T17:44:48.802+00:00</pubDate>
        <ttl>60</ttl>
        <item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1808422</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1808422</link>
        <title><![CDATA[MRI-based morphometric analysis of the patellofemoral joint: diagnostic modeling of knee pathologies in adolescents]]></title>
        <pubdate>2026-05-22T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Dusan Spasic</author><author>Goran Djuricic</author><author>Jelena Djokic Kovac</author><author>Bojan Bukva</author><author>Vladimir Radlovic</author><author>Milos Maletic</author><author>Stanislav Rajkovic</author><author>Marko Radulović</author>
        <description><![CDATA[IntroductionTo evaluate whether routinely measured MRI-based patellofemoral joint morphometric parameters can support diagnostic modeling of selected adolescent knee pathologies and to compare a conventional multivariable logistic regression baseline with machine-learning approaches.MethodsThis retrospective single-center pilot diganostic modeling study included 168 adolescents (97 girls, 71 boys, mean age 15.5 ± 1.7 years) who underwent knee MRI between January 2018 and December 2024 because of anterior knee pain or suspected patellofemoral structural abnormality. Thirteen patellofemoral morphometric parameters were measured by two radiologists. Three binary MRI endpoints were modeled: composite chondromalacia, a composite endpoint of ACL injury or patellar bone bruise, and patellar retinacular lesion. Baseline multivariable logistic regression was compared with machine-learning approaches using chronological training, validation, and test splits. Additional gradient-boosting comparators were evaluated, and uncertainty was quantified using bootstrap confidence intervals on the independent test set.ResultsIn multivariable logistic regression, no individual continuous morphometric predictor reached statistical significance for any endpoint. After correction of the model-selection procedure, predictive performance proved endpoint-specific rather than uniformly strong. For composite chondromalacia, discrimination remained weak. For the ACL injury/patellar bone bruise composite, machine-learning models showed only modest improvement in point estimates over logistic regression, but confidence intervals for differences crossed zero. The strongest reproducible signal was observed for patellar retinacular lesions. After correction of model selection and bootstrap-based uncertainty estimation, a morphometric-only CatBoost model achieved an AUC of 0.85 (95% CI 0.68–0.97) and balanced accuracy of 0.79 (95% CI 0.61–0.94), while a morphometric-only LightGBM model achieved an AUC of 0.84 (95% CI 0.64–0.97) and balanced accuracy of 0.76 (95% CI 0.59–0.88).DiscussionIn adolescents, routine patellofemoral morphometrics do not provide uniformly strong diagnostic discrimination across all MRI-defined knee pathologies studied here. Their most convincing predictive value was observed for patellar retinacular lesions, whereas performance for composite chondromalacia and the ACL injury/patellar bone bruise composite remained limited. These findings support a narrower interpretation of clinical utility and justify further validation in larger external cohorts.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1797587</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1797587</link>
        <title><![CDATA[Neuro-symbolic NLP: taxonomy, assessment, and directions]]></title>
        <pubdate>2026-05-22T00:00:00Z</pubdate>
        <category>Systematic Review</category>
        <author>Stergios Chatzikyriakidis</author><author>Shalom Lappin</author>
        <description><![CDATA[Neuro-symbolic (NeSy) approaches promise to overcome the limitations of purely neural and purely symbolic NLP. In this paper we survey recent development in NeSy NLP and propose a system classification framework that combines Kautz's integration types with Lappin's injective-federative distinction. We then apply this taxonomy and show that even though federative architectures consistently outperform injective approaches, they remain underexplored. We assess performance across compositional generalization, reasoning, and robustness benchmarks, examine existing attempts at linguistic theory integration, and show how the taxonomy can guide future architectures that preserve the strengths of formal linguistic frameworks. We conclude with directions for scaling federative systems and exploring tighter integration.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1759758</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1759758</link>
        <title><![CDATA[An open-source optimization model for sustainable open-pit mine production scheduling]]></title>
        <pubdate>2026-05-21T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Justina Senam Lotsu</author><author>Gilbert Yaw Bimpong</author><author>Kwaku Boakye</author>
        <description><![CDATA[Open-pit mine production scheduling is a complex optimization problem that requires balancing economic performance with operational feasibility and environmental responsibility. While significant advances have been made in mathematical formulations, many existing approaches remain computationally demanding, lack transparency, or are implemented within proprietary systems that limit reproducibility. This study presents a fully reproducible, open-source Python-based optimization framework for open-pit production scheduling that integrates sustainability considerations directly into decision-making. The model employs a mixed-integer “by” formulation with three-dimensional cone-based precedence constraints and incorporates environmental penalties into block valuations to enable ESG-aligned optimization. The framework is designed to be dataset-agnostic and extensible, supporting benchmarking and adaptation to different mining scenarios. The approach is demonstrated using a synthetic block model of 602 blocks over a 12-period planning horizon. The optimization achieved a discounted Net Present Value (NPV) of approximately USD 674.83 million while strictly satisfying precedence, capacity, and operational constraints. Results show that the integration of environmental penalties influences block selection and extraction sequencing, enabling more sustainable scheduling outcomes with only a moderate reduction in economic performance. Sensitivity analyses further confirm the robustness of the framework under varying economic and operational conditions. The study demonstrates that open-source optimization can provide a transparent, adaptable, and effective alternative to proprietary mine planning tools. By combining reproducibility, sustainability integration, and computational efficiency, the proposed framework establishes a practical baseline for future research and large-scale applications in sustainable mine planning.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1794125</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1794125</link>
        <title><![CDATA[KG-HiAttention: synergizing AI-based knowledge graphs and deep learning for explainable software vulnerability analysis]]></title>
        <pubdate>2026-05-21T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Francisco Pinto-Santos</author><author>Carolina Zato</author><author>Héctor Quintián</author><author>Tian Cheng Li</author><author>Pablo Chamoso</author>
        <description><![CDATA[Software vulnerability analysis is critical for maintaining secure and reliable systems, yet traditional Deep Learning (DL) models often act as “black boxes,” lacking transparency and failing to leverage the explicit structural semantics of code. In this paper, we propose KG-HiAttention, a novel neuro-symbolic framework that synergizes sub-symbolic deep learning with symbolic AI-based Knowledge Graphs (KGs). We construct a CPG-inspired lightweight program graph for each software function, approximating control-flow (CFG) and data-flow (DFG) dependencies through line-level edges. This symbolic structure is processed by a Graph Attention Network (GAT) and fused with semantic embeddings from a pre-trained CodeT5 encoder through multimodal fusion (concatenation and MLP classifier). Experiments on the real-world BigVul dataset show that KG-HiAttention achieves competitive performance (AUC-ROC 0.763 ± 0.009, five seeds), statistically equivalent to a strong Hybrid Ensemble baseline, while improving specificity from 0.321 (baseline) to 0.458 and providing graph-based explainability that the baseline cannot offer.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1831527</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1831527</link>
        <title><![CDATA[Malus’s law-enhanced Michelson interferometer with PSO-based calibration and data-driven error compensation for medical micro-displacement measurement]]></title>
        <pubdate>2026-05-21T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Yibo Wang</author><author>Yuetong Lv</author><author>Luyang Xie</author><author>Shilian Dong</author>
        <description><![CDATA[BackgroundHigh-precision micro-displacement measurement is crucial for applications ranging from semiconductor manufacturing to biomedical diagnostics. However, conventional Michelson interferometry is fundamentally limited by the light source’s coherence length and the inefficiency of manual fringe counting.MethodsThis study introduces a modified Michelson interferometer that operates on Malus’s law. The design converts the linear micro-displacement of a movable mirror into the rotation angle of a polarizer via mechanical coupling, which shifts the measurement principle from interference fringe observation to intensity modulation. This conversion establishes a quantitative relationship between displacement and light intensity, enabling automatic photoelectric detection. Additionally, an intelligent processing module was developed to support this hardware. This module includes a Particle Swarm Optimization (PSO) algorithm for the joint calibration of hardware parameters, an analytic inverse mapping for primary displacement computation, and a Gaussian Process Regression (GPR) model to compensate for residual instrument errors while providing per-measurement uncertainty bounds.ResultsThe proposed system successfully overcomes the coherence-length constraints of traditional interferometry. The integration of structural modifications, intelligent parameter calibration, and data-driven error compensation establishes a novel paradigm for measuring micro-displacement.ConclusionThe Malus’s law-enhanced Michelson interferometer provides a robust and automated alternative to conventional systems. The technology demonstrates significant potential for biomedical micro-displacement monitoring, particularly for the non-contact acquisition of physiological signals in clinical settings.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1825365</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1825365</link>
        <title><![CDATA[Protocol-constrained AI enhances tacrolimus dosing accuracy in kidney transplant care]]></title>
        <pubdate>2026-05-21T00:00:00Z</pubdate>
        <category>Brief Research Report</category>
        <author>Benjamin Bizer</author><author>Oscar A. Garcia Valencia</author><author>Flora Kincses</author><author>Jose Arriola-Montenegro</author><author>Charat Thongprayoon</author><author>Jing Miao</author><author>Wisit Cheungpasitporn</author>
        <description><![CDATA[BackgroundTacrolimus dosing after kidney transplantation is complex, highly individualized, and prone to variability, which can impact graft outcomes. While machine learning (ML) approaches have been used primarily to predict tacrolimus concentrations, large language models (LLMs) may enable protocol-constrained clinical decision support by generating dosing recommendations aligned with established treatment guidelines.MethodsWe developed TacroDose AI, a protocol-constrained LLM based on GPT-4, to generate tacrolimus dosing recommendations aligned with institutional guidelines. Using 300 structured simulated clinical scenarios, we evaluated protocol adherence, error patterns, and reproducibility of model-generated dosing recommendations. Following review of initial outputs, a refined prompt (TacroAI 2.0) was implemented to strengthen protocol constraints and structured output verification, and performance was reassessed.ResultsTacroDose AI achieved 72.9% protocol adherence, with 27.1% protocol deviations, including 13.9% sentinel errors with potential clinical significance. Prompt refinement substantially improved performance: TacroAI 2.0 achieved 91.7% adherence, reduced sentinel errors to 1.0%, and improved reproducibility from 77.3 to 86.7% (all p < 0.01). Although rounding discrepancies increased, these represented minor numerical differences without clinical relevance. Performance improvements were observed across subtherapeutic, therapeutic, and supratherapeutic tacrolimus scenarios.ConclusionProtocol-constrained LLMs can produce guideline-concordant tacrolimus dosing recommendations with high adherence and improved reliability in simulated clinical settings. These findings highlight a potential framework for integrating generative AI with rule-based clinical protocols to support safe medication management. With further validation using real-world data, such systems could be integrated into electronic health records to support clinician-supervised, protocol-based immunosuppressive dosing in transplant care.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1751832</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1751832</link>
        <title><![CDATA[Perceived benefits and constraints of artificial intelligence integration in teachers’ college libraries: a TAM-based study]]></title>
        <pubdate>2026-05-21T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Inos Chibidi</author><author>Logic Magwa</author>
        <description><![CDATA[The Fourth Industrial Revolution (4IR) has accelerated the adoption of Artificial Intelligence (AI) across knowledge intensive sectors, yet its integration in Library and Information Services (LIS) within resource constrained educational environments remains limited and under examined. This empirical paper seeks to explore the impact of AI integration in LIS and the associated challenges. This research examines the various applications of AI in libraries. The paper intends to identify the benefits and challenges associated with AI integration in libraries. This study adopted a qualitative descriptive design informed by phenomenological principles to study how AI application is perceived by key stakeholders to be beneficial and what barriers constrain AI uptake, and in what new areas AI can be applied in teachers’ college libraries. The study was anchored to the Technology Acceptance Model (TAM) where the effect of Perceived Usefulness (PU) and Perceived Ease of Use (PEOU) on the stakeholders’ preparedness to adopt AI was analysed as an interpretive lens. Sixty participants (library staff, ICT experts and Computer Science students) were interviewed in-depth, participated in focus group discussions, and were observed using structured observations. All data was analysed thematically using Braun and Clarke’s six-step framework. Evidence found that there was no real implementation of AI in academic libraries. Actual usage was almost non-existent, mainly automated processes within existing library systems, such as those integrated within Koha. Nonetheless, the participants perceived AI as potentially useful for automating mundane tasks, increasing ease in locating information, providing an improved user experience, and for continuous availability through the use of chatbots. In spite of the strong perceived usefulness, the actual PEOU and institutional preparedness for AI are limited by infrastructure challenges, lack of funds, limited digital literacies of users, ethical issues, and wider issues of digital disparity. The study stresses the need for a context-specific AI governance strategy, building capacity of all stakeholders, and adoption of a phased approach in low-resource academic libraries. The findings provide new insights into Global South literature by presenting an in-depth, multi-stakeholder view of teachers’ college AI readiness, emphasizing the interplay between technological novelty, infrastructural challenges, and ethics.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1836120</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1836120</link>
        <title><![CDATA[Dynamic coherence windows: a multi-scale structural coherence measurement framework for AI systems]]></title>
        <pubdate>2026-05-21T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Christian St-Louis</author>
        <description><![CDATA[Assessing the structural integrity of AI system outputs is typically based on surface-level metrics such as fluency or local coherence. This paper proposes an alternative perspective: measuring structural coherence as a multi-scale property of system outputs. We introduce the Dynamic Coherence Window (DCW) framework, which models structural viability as bounded behavior within coherence thresholds derived from the system’s internal organization. The framework defines a set of structural defect variables capturing distinct modes of degradation, along with two key state variables—the coherence margin m and stability parameter Λ—that jointly characterize system state. As a conceptual extension, we introduce the Cognitive Immune System (CIS), a theoretical evaluation mechanism that assesses the structural impact of new information prior to integration. The CIS defines four decision pathways (accept, reject, quarantine, reframe), including a human-mediated mechanism for integrating structurally incompatible inputs. We present CMCI v8.1.4, an implementation of the framework, and evaluate it through large-scale simulation (N = 10,000), targeted text analysis (N = 21), a controlled human-vs-LLM benchmark (N = 60), and cross-benchmark evaluation (N = 96). Results are consistent with the interpretation that the framework measures a structural dimension of coherence distinct from surface-level metrics under controlled conditions. These findings provide preliminary empirical support for the hypothesis that structural coherence constitutes a measurable and distinct dimension of system output quality. The present work introduces and evaluates a structural coherence measurement framework under controlled conditions. Validation in real-world deployment settings remains an open direction for future research.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1827586</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1827586</link>
        <title><![CDATA[Evaluating AI adoption challenges in healthcare using a Multi-Criteria Decision-Making approach: implications for predictive risk analytics]]></title>
        <pubdate>2026-05-20T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Pulidindi Venugopal</author><author>Pratibha Garg</author><author>Chand Prakash</author><author>Sunil Kumar</author><author>Neha Gupta</author>
        <description><![CDATA[IntroductionArtificial intelligence (AI) adoption in predictive healthcare risk analytics can transform clinical decision-making and resource management; however, its implementation is limited by various socio-technical challenges.MethodsThis study aims to identify and prioritize the key barriers influencing AI adoption using an integrated Decision-Making Trial and Evaluation Laboratory (DEMATEL) and Analytic Hierarchy Process (AHP) model. Based on a thorough literature review and expert validation, fifteen challenges were identified and categorized into five dimensions: technological, data-related, organizational, human/social, and ethical-regulatory. The DEMATEL method was used to analyse causal relationships among the challenges, while AHP was employed to determine their relative importance through hierarchical weighting.ResultsThe results indicate that the most influential structural drivers affecting adoption include data privacy and protection, data quality and completeness, lack of AI governance, and system interoperability, while leadership and strategic alignment emerge as critical organizational enablers. Data-related and governance-oriented challenges emerged as primary causal factors, whereas human-centred and ethical concerns predominantly appeared as dependent outcomes.DiscussionThe study concludes that successful adoption of AI in predictive healthcare analytics requires strong leadership support, robust data governance systems, and transparent and interoperable technologies, and provides a structured roadmap for healthcare organizations to achieve scalable and reliable predictive analytics implementation.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1803863</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1803863</link>
        <title><![CDATA[Hybrid machine learning forecasting for resilient and sustainable pharmaceutical supply chains under regulatory and seasonal disruption]]></title>
        <pubdate>2026-05-20T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Khalid Yahya</author><author>Mehdi Safaei</author><author>Saleh Al Dawsari</author>
        <description><![CDATA[IntroductionDemand forecasting in pharmaceutical supply chains is not a simple task. In regulated markets it becomes more difficult, because seasonality, epidemic waves, and also policy changes can make demand behavior unstable. This study proposes a hybrid residual learning approach for forecasting pharmaceutical demand in Türkiye.MethodsThe model uses Support Vector Regression (SVR) together with Deep Neural Networks (DNN). In this structure, SVR estimates the main or baseline part of demand, and DNN tries to learn the remaining nonlinear residual variation. The framework was tested with real ERP-based demand data, including 10 critical pharmaceutical products in a 24-month period. For evaluation, temporal holdout testing was used. The model was also compared with ARIMA, Prophet, Random Forest, XGBoost, and LSTM. Statistical validation was done by paired t-tests and Diebold–Mariano tests.ResultsThe proposed SVR–DNN framework performed better than the standalone SVR and DNN models. It also stayed as the strongest model when it was compared with the wider benchmark models. The hybrid model gave the lowest forecasting errors, and it showed the highest explanatory performance among the tested models.DiscussionThe results show that when baseline demand estimation is separated from residual correction, forecasting performance can be improved in pharmaceutical demand conditions that are sensitive to disruptions. SHAP analysis also helped the interpretation of model, because it showed the main factors that affect demand variation. The proposed framework gives an interpretable and context-aware forecasting model for pharmaceutical supply chains working under regulatory and seasonal disruption.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1844338</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1844338</link>
        <title><![CDATA[A vision language model for generating XML-based organ-level plant architecture representations of cowpea from simulated images]]></title>
        <pubdate>2026-05-20T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Heesup Yun</author><author>Isaac Kazuo Uyehara</author><author>Ioannis Droutsas</author><author>Earl Ranario</author><author>Christine H. Diepenbrock</author><author>Brian N. Bailey</author><author>J. Mason Earles</author>
        <description><![CDATA[Three-dimensional (3D) procedural plant architecture models have emerged as an important tool for simulation-based studies of plant structure and function, extracting plant architectural parameters from field measurements, and for generating realistic plants in computer graphics. However, measuring the architectural parameters for these models at the field and population scales remains prohibitively labor-intensive. We present a novel algorithm that generates the 3D plant architecture from an image, to create a functional structural plant model from an image that reflects organ-level geometric and topological parameters, providing a more comprehensive representation of the plant’s architecture. Instead of using 3D sensors or processing multi-view images with computer vision to obtain the 3D structure of plants, we propose a method that generates token sequences containing a procedural definition of the plant architecture. This work uses only synthetic images for training and testing, where “exact” architectural parameters were known, which allowed for testing of the hypothesis that organ-level architectural parameters could be extracted from imagery data using a vision language model (VLM). A synthetic dataset of cowpea plant images was generated using the Helios 3D plant simulator, with the detailed plant architecture encoded in XML files. We developed a plant architecture tokenizer for the XML file defining plant architecture, converting it into a token sequence that a language model can predict. Then, a VLM was trained to predict plant architecture token sequences from images. Our results demonstrate that the model can predict plant architecture tokens with an F1 score of 0.73 in a teacher-forcing method. Evaluation of the model was performed through autoregressive generation, achieving a BLEU-4 score of 94.00% and a ROUGE-L score of 0.5182. Our model achieves lower MAPE than feature regression-based methods in estimating bulk plant-level traits that require understanding of the occluded 3D structure of the plant, such as leaf count and leaf area. We conclude that generating plant architecture and parameter extraction from synthetic imagery are feasible using a VLM approach, supporting future extension to real imagery.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1814362</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1814362</link>
        <title><![CDATA[Image processing and AI techniques for climate change detection using remote sensing: a comprehensive review]]></title>
        <pubdate>2026-05-20T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Anirudh Agarwal</author><author>Shreya Kumar</author><author>G. K. Rajini</author><author>Indragandhi Vairavasundaram</author>
        <description><![CDATA[Climate change is accelerating spatially complex transformations in land, water, coasts, cryosphere, and ecosystems, creating a critical need for reliable, scalable, and timely monitoring based on Earth observation imagery. Conventional approaches that rely on sparse in-situ measurements, manual image interpretation, and simple spectral indices or thresholding often fail to capture subtle, heterogeneous, and multiscale changes, and they do not scale to today's multi-sensor, multi-temporal satellite archives. This review synthesizes image processing and AI techniques applied to optical, SAR, thermal, and hyperspectral remote sensing for climate change detection, covering classical change detection methods, machine learning classifiers, deep learning architectures (including Siamese and segmentation networks), spatio-temporal models for satellite image time series, and multi-sensor fusion, across application domains such as land use/land cover (LULC) and deforestation, hydrology and flooding, coastal and mangrove dynamics, cryospheric change, urban heat, ecosystems, and natural hazards. In addition, we analyze how these methods are evaluated using common performance metrics–Overall Accuracy (OA), precision, recall, F1-score, Intersection over Union (IoU), Kappa coefficient, and error measures such as RMSE–and discuss key challenges related to data quality and annotation, domain shift and generalization, computational and operational constraints, interpretability, and integration with climate and impact models. The distinctive contribution of this review is a unified method-application taxonomy that explicitly links algorithm families to specific climate monitoring tasks, a systematic comparison of reported performance metrics that clarifies trade-offs between techniques under different data and class-imbalance conditions, and a practical decision framework to guide researchers and practitioners in selecting appropriate image processing and AI approaches for given sensors, regions, and operational requirements, while outlining promising future directions such as foundation models, standardized benchmarks, and interoperable climate decision-support systems. Across the reviewed literature, deep learning approaches consistently demonstrate higher accuracy (e.g., improved IoU and F1-scores) in complex and heterogeneous environments, while classical methods remain effective for large-scale and data-scarce applications. However, significant gaps persist in model generalization across regions, availability of labeled datasets, and integration of multi-sensor time-series data.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1828950</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1828950</link>
        <title><![CDATA[A novel lightweight deep learning model for early prediction of cardiovascular disease]]></title>
        <pubdate>2026-05-20T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Nasir Gul</author><author>Aurangzeb Khan</author><author>Mazliham Mohd Su'ud</author><author>Muhammad Mansoor Alam</author><author>Danyal Skandri</author>
        <description><![CDATA[Cardiovascular Disease (CVD) is still the main cause of death globally. Hence, to have timely clinical intervention, there is a need for the prediction of early risk models which are accurate and dependable. Here is a lightweight and strong artificial intelligence-based system for the early prediction of CVD using clinical data. We have created an end-to-end method comprising data preprocessing, stratified train and test splitting, and class imbalance treatment by SMOTE exclusively on the training set to ensure that there is no data leakage. We evaluate a series of machine learning (ML) and deep learning (DL) models, including Logistic Regression (LR), Decision Tree (DT), K-Nearest Neighbors (KNN), Random Forest (RF), Support Vector Machine (SVM), and various Artificial Neural Network (ANN) architectures, systematically. In order to check the robustness and generalizability of the models proposed, we conduct a k-fold cross-validation procedure and the performance measures are reported using evaluation matrices such as accuracy, precision, recall, F1-score, and ROC curve along with statistical metrics (mean and standard deviation). The results from the experiments show that the fine-tuned four-layer ANN yields the best prediction performance. Nevertheless, and in contrast to conventional studies, evaluation of the models is strongly based on robust validation and statistical reliability and not only on accuracy.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1789644</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1789644</link>
        <title><![CDATA[Systematic review of artificial intelligence use in behavioral analysis of invertebrate and larval model organisms: methods, applications and future recommendations]]></title>
        <pubdate>2026-05-19T00:00:00Z</pubdate>
        <category>Systematic Review</category>
        <author>Zuzanna Stępnicka</author><author>Natalia Piórkowska</author><author>Malwina Brożyna</author><author>Tomasz Matys</author><author>Adam Junka</author>
        <description><![CDATA[Invertebrate and larval model organisms such as Drosophila melanogaster, Caenorhabditis elegans, Danio rerio larvae, and Galleria mellonella are increasingly employed in biomedical, toxicological, and ecological research. Their behavioral responses serve as sensitive indicators of functional changes, yet traditional methods of observation remain low-throughput, subjective, and poorly scalable. Artificial intelligence (AI), including machine learning (ML) and deep learning (DL), has emerged as a powerful alternative, enabling automated and unbiased analysis of highly dimensional behavioral data. Here, we present the first systematic review comprehensively mapping the use of AI in behavioral analysis of invertebrate and larval organisms. Following PRISMA 2020 guidelines, we screened literature published between 2015 and May 2025. A total of 97 eligible studies were analyzed for model organisms investigated, AI methods applied, input data characteristics, preprocessing pipelines, model architectures, and evaluation metrics. We observed a steep increase in publications, from only 2 in 2015 to 97 by mid-2025, with the majority originating from the USA, China, and Germany. The most frequently studied organisms included D. melanogaster, C. elegans, and zebrafish larvae, alongside aquaculture and pest species. Since 2021, DL models, particularly convolutional neural networks (CNNs), including YOLO models, and pose estimation frameworks such as DeepLabCut have dominated the field, while supervised ML remains common for classification tasks, and unsupervised learning is primarily applied in exploratory clustering. Input data were typically video or image recordings, but reporting practices were highly inconsistent regarding resolution, frame rate, preprocessing steps, and model training details. Evaluation metrics also varied widely, limiting reproducibility and cross-study comparisons. To address these gaps, we propose a standardized reporting framework encompassing input data specifications, preprocessing pipelines, model architecture, and evaluation metrics. Such standardization will enhance transparency, reproducibility, and comparability across laboratories. AI-driven behavioral analysis has the potential to accelerate drug discovery, toxicology, and environmental monitoring while reducing reliance on vertebrate models in preclinical research.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1716935</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1716935</link>
        <title><![CDATA[Artificial intelligence in carotid research: a 25-year bibliometric analysis of global trends and future directions]]></title>
        <pubdate>2026-05-19T00:00:00Z</pubdate>
        <category>Systematic Review</category>
        <author>Shi-Chao Zhu</author><author>Jia-Xin Dong</author><author>Yu-Dan Wu</author><author>Yue Gao</author><author>Rui Gao</author><author>Yong-Hui Yuan</author><author>Shuang Wang</author><author>Guang-Wei Zhang</author>
        <description><![CDATA[BackgroundArtificial intelligence (AI) technology advancements have revolutionized carotid artery research, driving innovations in diagnostics and treatment. The exponential growth of studies underscores the critical need for systematic analysis to ensure clinical relevance and algorithmic robustness.ObjectiveTo systematically evaluate the status of AI applications in carotid artery research, identify emerging themes and track development trends, and establish a guiding framework for future research.MethodsA retrospective bibliometric analysis of Web of Science Core Collection data, Scopus, and PubMed databases from 2000 to 2025 was performed, focusing on title/abstract/keyword queries related to AI-driven carotid artery research. Network visualizations and structural analyses generated by CiteSpace reveal evolving thematic clusters and emerging frontiers in this interdisciplinary field.ResultsA total of 1,220 relevant publications were identified in this study, with an overall increasing trend in publication volume. China and the United States emerged as the primary contributing countries. Research mainly focuses on early, accurate diagnosis, monitoring, individualized intervention of carotid artery disease, imaging omics analysis, and advanced physiological and pathological analysis. Recent progress is characterized by big data, multi-omics, multi-modality, and multi-scale integration, emphasizing precision medicine and full-process evaluation of disease management, marking a major shift in carotid research toward a data-driven approach.ConclusionThis bibliometric study employs visualization techniques to delineate AI’s transformative role in carotid artery research, demonstrating its potential to redefine research paradigms and drive sustained advancements through advanced data analytics.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1821975</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1821975</link>
        <title><![CDATA[Exploring the determinants of anemia in young adult women (20–24 years): the role of AI-based interventions in health management]]></title>
        <pubdate>2026-05-19T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Sireesha Guttapalam</author><author>A. M. Beulah</author><author>M. Niharika</author><author>C. Pradeepthi</author><author>D. Madhavi</author>
        <description><![CDATA[BackgroundAnemia is a deficiency disorder in healthy red blood cells or hemoglobin is a widespread health concern among young adult women, effects considerable impact on physical health, productivity, and overall quality of life. Despite its high prevalence, effective diagnosis and management remain challenging due to the complex interaction of the causes, intensified by limited awareness and inadequate health concern behavior.ObjectiveThe present study aimed to study the determinants of anemia and development of AI App for screening anemia and management particularly for young women.MethodsA total of 545 women aged 20–24 years were examined in the study. A structured questionnaire was designed to acquire socio-demographic characteristics and to assess dietary and lifestyle factors influencing the probability of anemia risk. Blood samples were collected to evaluate key hematological parameters. Furthermore, an AI (artificial intelligence)-based anemia risk assessment and mobile health intervention was developed and effectiveness of the tool was evaluated using machine learning models.ResultsMild anemia constituted the largest proportion of the study population (50.3%), followed by normal hemoglobin status (27.5%). The machine learning model accuracy was 74.39% and human data diagnostic accuracy of the AI-based anemia assessment system was found to be 71%, respectively.ConclusionThis digital health approach also aims to enhance anemia awareness, prevention, and management. Integrating AI into anemia care holds promise for delivering accurate, timely, and personalized interventions, particularly in resource-restricted settings, thereby improving health outcomes for young women and reducing the societal burden of anemia.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1776338</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1776338</link>
        <title><![CDATA[The validity and reliability of a real-time AI-based neck exercise program among young adults in Thailand: evaluation of accuracy and execution time]]></title>
        <pubdate>2026-05-19T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Yadanuch Boonyaratana</author><author>Nacha Chondamrongkul</author><author>Vitsarut Buttagat</author><author>Pattanasin Areeudomwong</author>
        <description><![CDATA[Neck pain caused by weakened muscles and decreased strength may be alleviated with exercise. Integrating digital technology, such as artificial intelligence (AI), into neck exercise programs may improve their accuracy and effectiveness. This study aims to evaluate the validity and reliability of an AI-based neck exercise program to measure accuracy and execution time. The method included evaluating the validity and reliability of a real-time AI neck exercise program among 30 healthy participants aged 18–29 years, across five exercises. In the results, the outcome variables included the content validity index (IOC) for exercise accuracy and execution time. Reliability was evaluated using the intraclass correlation coefficient (ICC), and associations between variables were analyzed using Pearson’s correlation coefficient. The content validity assessment indicated high validity of the AI-based neck exercise program, with IOC values between 0.86 and 1.00 across all exercises. Moderate reliability was observed for exercise accuracy (ICC = 0.63) and execution time (ICC = 0.622). Higher exercise accuracy was associated with shorter execution time; however, this relationship should be interpreted with caution, as it does not imply causality.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1779276</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1779276</link>
        <title><![CDATA[AI snake oil? A risk/benefit analysis for toxicology]]></title>
        <pubdate>2026-05-19T00:00:00Z</pubdate>
        <category>Hypothesis and Theory</category>
        <author>Thomas Hartung</author><author>Mohan Rao</author><author>Mamta Behl</author><author>Alexandra Maertens</author>
        <description><![CDATA[Artificial intelligence (AI) is increasingly used to support predictive, mechanistic, and human-relevant toxicology at scale. However, its integration into regulatory science - particularly in drug development - remains uneven, because encouraging technical performance has not yet translated automatically into regulatory trust. Representative AI toxicology studies now span datasets from roughly 103 chemicals to >3 × 104 peptide or chemical records and report performance ranging from modest in prospective screening settings to strong on narrower, well-curated endpoints. This manuscript presents a critical analysis of the dual nature of AI in toxicology. We review the state of the art in AI-enabled applications, ranging from Green Toxicology and the Human Exposome to specific challenges in safety assessment for biologics and synthetic peptides. Particular attention is given to the gap between rapid model development and regulatory acceptance, highlighted by the challenges of model interpretability, dataset bias, insufficient external validation, and the assessment of complex endpoints like immunogenicity. To navigate these complexities, we discuss the next-generation “e-validation” framework and emphasize the TREAT principle - Trustworthiness, Reproducibility, Explainability, Applicability, and Transparency - as a foundation for building regulatory trust. We hypothesize that AI-based methods in toxicology can achieve regulatory acceptance when they satisfy the TREAT criteria and undergo continuous e-validation within a clearly defined context of use. This framework distinguishes credible AI applications from “snake oil” by establishing measurable criteria for trust-building, including dataset provenance, external validation, uncertainty characterization, and life-cycle monitoring. We argue that AI is neither a miracle cure nor a technological illusion, but a powerful evidence engine that can contribute to a more predictive and ethical toxicological science when it is rigorously validated.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1794183</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1794183</link>
        <title><![CDATA[Deep learning classification of reproductive tissue from ultrasound: sex determination in red abalone (Haliotis rufescens)]]></title>
        <pubdate>2026-05-18T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Edwin A. Solares</author><author>Anthony Tong</author><author>Sohyun Yoo</author><author>Welokiheiakeaeloa Gosline-Niheu</author><author>Kevin Jacob</author><author>Gordon Feliz</author><author>Sachin Loecher</author><author>Yuan Zhai</author><author>Maggie Mah</author><author>Sara E. Boles</author><author>Ayodeji E. Fagbohun</author><author>Jackson A. Gross</author>
        <description><![CDATA[IntroductionAccurate sex determination is critical for spawning success in both conservation breeding programs and commercial aquaculture, yet non-invasive methods remain limited in abalone species. Traditional approaches rely on visual inspection, which requires substrate detachment, can cause injury, and may induce premature gamete release. Here, we present the first application of machine learning to automate sex classification in red abalone (Haliotis rufescens) using non-invasive ultrasound imaging technology.MethodsWe developed a labeled dataset of 246 high-quality ultrasound images from 44 individuals and benchmarked seven convolutional neural network architectures: VGG16, VGG19, ResNet50, ResNet101, YOLOv8, YOLOv11, and a custom convolutional neural network. Data partitioning by individual identity was essential to prevent artificially inflated accuracy from image leakage across splits.ResultsThe YOLOv8 architecture achieved the highest test accuracy of 85.7% (precision: 0.905 male, 0.816 female; recall: 0.845 male, 0.899 female), outperforming both classical architectures and custom models. Interestingly, a custom reverse VGG architecture with decreasing channel depth outperformed standard VGG models, suggesting that early channel compression may help combat ultrasound speckle noise.DiscussionFeature activation maps confirmed that models learned to attend to gonadal tissue rather than imaging artifacts. We also demonstrate inference on NVIDIA Jetson edge devices, enabling real-time classification suitable for field deployment. This framework establishes the feasibility of automated, non-lethal sex determination for mollusks and lays the groundwork for applications to endangered abalone species where traditional invasive methods are prohibited.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frai.2026.1748985</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frai.2026.1748985</link>
        <title><![CDATA[Artificial intelligence techniques for classification of Alzheimer's disease using neuroimaging data: a review]]></title>
        <pubdate>2026-05-18T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Y. Nibila</author><author>M. Sivagami</author>
        <description><![CDATA[Alzheimer's disease (AD) is a gradually advancing brain disorder marked by memory impairment. The incurable, progressive nature of the disease leads to the dementia stage. Treatment is effective in the early stage, and it can be controlled but not cured. Artificial Intelligence (AI) learning models are used in medical science to detect and classify diseases into specific categories. Features are extracted from medical images and trained using AI learning models to perform an accurate diagnosis of AD. Recent advancements in machine learning (ML) and deep learning (DL) models have demonstrated significant potential in identifying AD across various data modalities, including neuroimaging, genetic information, and clinical assessments. This study focuses on the application of advanced ML and DL techniques in the identification and classification of AD, including regression models, decision trees, random forests, support vector machines (SVMs), k-nearest neighbors (KNNs), ensemble models, convolutional neural networks (CNNs), recurrent neural networks (RNNs), and generative adversarial networks (GANs). Each model is analyzed for its strengths, limitations, and performance metrics, with particular emphasis on the importance of data preprocessing and augmentation techniques to improve model accuracy and robustness. The review highlights that multimodal approaches, particularly the fusion of MRI and PET data, enhance classification accuracy compared to single-modality models. Additionally, transfer learning techniques have shown promise in overcoming data limitations by leveraging pretrained models. The review also highlights the critical role of evaluation metrics in assessing model performance, emphasizing the need for a diverse set that includes accuracy, precision, recall, F1-score, and Cohen's Kappa. The study identifies gaps in the current literature, including underreporting of certain metrics and the need for more comprehensive evaluations, and provides recommendations for future research. Finally, this study discusses the challenges and opportunities in the field, including improving model generalizability, enhancing interpretability, advanced data preprocessing and augmentation, integration with clinical workflows, and multimodal data fusion. This review provides consolidated information that may be useful for researchers, clinicians, and data scientists, offering insights into current trends, challenges, and future research directions in AI-driven AD detection.]]></description>
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